Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1.

ABSTRACT:

Rationale

Because acute lung injury is a sporadic disease produced by heterogeneous precipitating factors, previous genetic analyses are mainly limited to candidate gene case-control studies.

Objectives

To develop a genome-wide strategy in which single nucleotide polymorphism associations are assessed for functional consequences to survival during acute lung injury in mice.

Methods

To identify genes associated with acute lung injury, 40 inbred strains were exposed to acrolein and haplotype association mapping, microarray, and DNA-protein binding were assessed.

Measurements and main results

The mean survival time varied among mouse strains with polar strains differing approximately 2.5-fold. Associations were identified on chromosomes 1, 2, 4, 11, and 12. Seven

SUBMITTER: Leikauf GD 

PROVIDER: S-EPMC3137140 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature