A procedure to statistically evaluate agreement of differential expression for cross-species genomics.

ABSTRACT:

Motivation

Animal models play a pivotal role in translation biomedical research. The scientific value of an animal model depends on how accurately it mimics the human disease. In principle, microarrays collect the necessary data to evaluate the transcriptomic fidelity of an animal model in terms of the similarity of expression with the human disease. However, statistical methods for this purpose are lacking.

Results

We develop the agreement of differential expression (AGDEX) procedure to measure and determine the statistical significance of the similarity of the results of two experiments that measure differential expression across two groups. AGDEX defines a metric of agreement and determines statistical significance by permutation of each experiment's group labels. Additio

SUBMITTER: Pounds S 

PROVIDER: S-EPMC3137228 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature