Evidence for increased cardiovascular events in the fathers but not mothers of women with polycystic ovary syndrome.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is a familial syndrome, associated with multiple cardiovascular disease (CVD) risk factors. Thus, parents of affected women may have a higher prevalence of CVD events than the general population.

Methods

PCOS probands (n = 410) and their participating parents (n = 180 fathers and 211 mothers) were queried for CVD events in themselves and non-participating family members. In order to include the family CVD history of all parents, agreement between the proband and parental reports of CVD events was assessed. Estimated 10-year coronary heart disease (CHD) risk was calculated using the Framingham risk calculator. The National Health and Nutrition Examination Survey (NHANES) 2001-2002 database was used to generate gender, age and body m

SUBMITTER: Taylor MC 

PROVIDER: S-EPMC3137384 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature