MiR-335 and miR-34a Promote renal senescence by suppressing mitochondrial antioxidative enzymes.

ABSTRACT: The molecular basis for aging of the kidney is not well understood. MicroRNAs (miRNAs) contribute to processes such as development, differentiation, and apoptosis, but their contribution to the aging process is unknown. Here, we analyzed the miRNA expression profile of young (3-month) and old (24-month) rat kidneys and identified the biologic pathways and genes regulated by differentially expressed miRNAs. We observed upregulation of 18 miRNAs with aging, mainly regulating the genes associated with energy metabolism, cell proliferation, antioxidative defense, and extracellular matrix degradation; in contrast, we observed downregulation of 7 miRNAs with aging, principally targeting the genes associated with the immune inflammatory response and cell-cycle arrest. Bioinformatics analysis sugg

SUBMITTER: Bai XY 

PROVIDER: S-EPMC3137573 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature