Genome-wide analysis shows increased frequency of copy number variation deletions in Dutch schizophrenia patients.

ABSTRACT:

Background

Since 2008, multiple studies have reported on copy number variations (CNVs) in schizophrenia. However, many regions are unique events with minimal overlap between studies. This makes it difficult to gain a comprehensive overview of all CNVs involved in the etiology of schizophrenia. We performed a systematic CNV study on the basis of a homogeneous genome-wide dataset aiming at all CNVs ≥ 50 kilobase pair. We complemented this analysis with a review of cytogenetic and chromosomal abnormalities for schizophrenia reported in the literature with the purpose of combining classical genetic findings and our current understanding of genomic variation.

Methods

We investigated 834 Dutch schizophrenia patients and 672 Dutch control subjects. The CNVs were included if they we

SUBMITTER: Buizer-Voskamp JE 

PROVIDER: S-EPMC3137747 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature