Optimizing the concentration and bolus of a drug delivered by continuous infusion.

ABSTRACT: We consider treatment regimes in which an agent is administered continuously at a specified concentration until either a response is achieved or a predetermined maximum infusion time is reached. Response is an event defined to characterize therapeutic efficacy. A portion of the maximum planned total amount administered is given as an initial bolus. For such regimes, the amount of the agent received by the patient depends on the time to response. An additional complication when response is evaluated periodically rather than continuously is that the response time is interval censored. We address the problem of designing a clinical trial in which such response time data and a binary indicator of toxicity are used together to jointly optimize the concentration and the size of the bolus. We pro

SUBMITTER: Thall PF 

PROVIDER: S-EPMC3137757 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature