Potential Antidepressant Role of Neurotransmitter CART: Implications for Mental Disorders.

ABSTRACT: Depression is one of the most prevalent and debilitating public health concerns. Although no single cause of depression has been identified, it appears that interaction among genetic, epigenetic, biochemical, environmental, and psychosocial factors may explain its etiology. Further, only a fraction of depressed patients show full remission while using current antidepressants. Therefore, identifying common pathways of the disorder and using that knowledge to develop more effective pharmacological treatments are two primary targets of research in this field. Brain-enriched neurotransmitter CART (cocaine- and amphetamine-regulated transcript) has multiple functions related to emotions. It is a potential neurotrophic factor and is involved in the regulation of hypothalamic-pituitary-adrenal ax

SUBMITTER: Mao P 

PROVIDER: S-EPMC3138108 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature