Positive airway pressure initiation: a randomized controlled trial to assess the impact of therapy mode and titration process on efficacy, adherence, and outcomes.

ABSTRACT:

Study objectives

(1) To determine the efficacy of automatically adjusted positive airway pressure (APAP) with a comfort feature (A-Flex) at reducing apneas and hypopneas in participants with moderate to severe OSA. (2) To determine the relative difference between A-Flex, continuous positive airway pressure (CPAP), and APAP-derived optimal pressure for CPAP (CPAP(APAP)) on adherence to treatment. (3) To determine the relative difference between APAP with A-Flex, CPAP, and CPAP(APAP) on long-term change in functional outcomes.

Design

Randomized, double-blinded, 3-arm, multicenter trial.

Setting

University and Veterans Affairs medical centers.

Patients or participants

168 participants were randomized, and 140 completed the 180-day study.

Interventions

(1) A

SUBMITTER: Kushida CA 

PROVIDER: S-EPMC3138163 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature