A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma.

ABSTRACT:

Background

Osteosarcoma (OS) is a bone malignancy which occurs primarily in adolescents. Since it occurs during a period of rapid growth, genes important in bone formation and growth are plausible modifiers of risk. Genes involved in DNA repair and ribosomal function may contribute to OS pathogenesis, because they maintain the integrity of critical cellular processes. We evaluated these hypotheses in an OS association study of genes from growth/hormone, bone formation, DNA repair, and ribosomal pathways.

Methods

We evaluated 4836 tag-SNPs across 255 candidate genes in 96 OS cases and 1426 controls. Logistic regression models were used to estimate the odds ratios (OR) and 95% confidence intervals (CI).

Results

Twelve SNPs in growth or DNA repair genes were significantl

SUBMITTER: Mirabello L 

PROVIDER: S-EPMC3138419 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature