Persistent, biologically meaningful prostate cancer after 1 year of androgen ablation and docetaxel treatment.

ABSTRACT:

Purpose

Clinicians are increasingly willing to treat prostate cancer within the primary site in the presence of regional lymph node or even limited distant metastases. However, no formal study on the merits of this approach has been reported. We used a preoperative clinical discovery platform to prioritize pathways for assessment as therapeutic targets and to test the hypothesis that the primary site harbors potentially lethal tumors after aggressive treatment.

Patients and methods

Patients with locally advanced or lymph node-metastatic prostate cancer underwent 1 year of androgen ablation and three cycles of docetaxel therapy, followed by prostatectomy. All specimens were characterized for stage by accepted criteria. Expression of select molecular markers implicated in dise

SUBMITTER: Tzelepi V 

PROVIDER: S-EPMC3138635 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature