Effectiveness and causes for failure of surveillance of CDKN2A-mutated melanoma families.

ABSTRACT:

Background

For more than 25 years families with an increased susceptibility to melanoma have been under surveillance at our institution.

Objective

We sought to investigate the effectiveness of surveillance for CDKN2A-mutated families and causes for failure of the program in patients with more advanced tumors.

Methods

In a retrospective case-control study, Breslow thickness of melanomas diagnosed in relatives enrolled in the surveillance program were compared with melanomas of unscreened index patients. We investigated the influence of mode of detection and length of surveillance interval on outcome.

Results

Surveillance melanomas (n = 226, median thickness: 0.50 mm) had a significantly lower Breslow thickness (multiplication factor: 0.61 [95% confidence interva

SUBMITTER: van der Rhee JI 

PROVIDER: S-EPMC3138884 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature