Orbitofrontal dysfunction predicts poor prognosis in chronic migraine with medication overuse.

ABSTRACT: Chronic migraine patients are at risk of developing a medication overuse. Brain functional studies in these patients have demonstrated an orbitofrontal hypometabolism, persistent after overuse cessation. Orbitofrontal dysfunction is also present in addiction and thus could predispose migraineurs to medication overuse. The aim of this study was to investigate if orbitofrontal dysfunction can be demonstrated in patients with chronic migraine and medication overuse by performing a systematic neuropsychological evaluation focused on tests that assess frontal lobe function. Second, to establish whether it is related to the outcome of these patients. We prospectively studied 42 chronic migraine patients with medication overuse, 42 episodic migraineurs and 41 controls on a battery of neuropsychol

SUBMITTER: Gomez-Beldarrain M 

PROVIDER: S-EPMC3139058 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature