Genetic polymorphisms of matrix metalloproteinase 3 in primary sclerosing cholangitis.

ABSTRACT:

Background

The damaging cholestasis inherent to primary sclerosing cholangitis (PSC) results from bile duct stricturing because of progressive fibrosis. The matrix metalloproteinase 3 (MMP3) degrades a wide range of matrix components and is expressed by activated liver stellate cells, and so is a candidate for involvement with the fibrotic processes underlying PSC. Moreover, the MMP3 gene harbours polymorphisms associated with variation in its activity directly impacting clinical phenotypes.

Aims

We aimed to examine the influence of MMP3 polymorphisms on PSC risk and progression.

Methods

Nine single nucleotide polymorphisms (SNPs) tagging the common genetic variation of MMP3 were genotyped in 266 PSC patients and 407 controls. SNPs and inferred haplotypes were assesse

SUBMITTER: Juran BD 

PROVIDER: S-EPMC3139245 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature