Interactions between secondhand smoke and genes that affect cystic fibrosis lung disease.

ABSTRACT:

Context

Disease variation can be substantial even in conditions with a single gene etiology such as cystic fibrosis (CF). Simultaneously studying the effects of genes and environment may provide insight into the causes of variation.

Objective

To determine whether secondhand smoke exposure is associated with lung function and other outcomes in individuals with CF, whether socioeconomic status affects the relationship between secondhand smoke exposure and lung disease severity, and whether specific gene-environment interactions influence the effect of secondhand smoke exposure on lung function.

Design, setting, and participants

Retrospective assessment of lung function, stratified by environmental and genetic factors. Data were collected by the US Cystic Fibrosis Twin a

SUBMITTER: Collaco JM 

PROVIDER: S-EPMC3139475 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature