Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer.

ABSTRACT:

Background

Previous studies that were based primarily on small numbers of patients suggested that certain circulating proinflammatory cytokines may be associated with lung cancer; however, large independent studies are lacking.

Methods

Associations between serum interleukin 6 (IL-6) and interleukin 8 (IL-8) levels and lung cancer were analyzed among 270 case patients and 296 control subjects participating in the National Cancer Institute-Maryland (NCI-MD) case-control study. Results were validated in 532 case patients and 595 control subjects in a nested case-control study within the prospective Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Association with C-reactive protein (CRP), a systemic inflammation biomarker, was also analyzed. Associations b

SUBMITTER: Pine SR 

PROVIDER: S-EPMC3139587 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature