Lgt processing is an essential step in Streptococcus suis lipoprotein mediated innate immune activation.

ABSTRACT:

Background

Streptococcus suis causes invasive infections in pigs and occasionally in humans. The host innate immune system plays a major role in counteracting S. suis infections. The main components of S. suis able to activate the innate immune system likely include cell wall constituents that may be released during growth or after cell wall integrity loss, however characterization of these components is still limited.

Methodology/principal findings

[corrected] A concentrated very potent innate immunity activating supernatant of penicillin-treated S. suis was SDS-PAGE fractionated and tested for porcine peripheral blood mononucleated cell (PBMC) stimulating activity using cytokine gene transcript analysis. More than half of the 24 tested fractions increased IL-1β and IL-8 cy

SUBMITTER: Wichgers Schreur PJ 

PROVIDER: S-EPMC3139625 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature