Hyphal development in Candida albicans requires two temporally linked changes in promoter chromatin for initiation and maintenance.

ABSTRACT: Phenotypic plasticity is common in development. For Candida albicans, the most common cause of invasive fungal infections in humans, morphological plasticity is its defining feature and is critical for its pathogenesis. Unlike other fungal pathogens that exist primarily in either yeast or hyphal forms, C. albicans is able to switch reversibly between yeast and hyphal growth forms in response to environmental cues. Although many regulators have been found involved in hyphal development, the mechanisms of regulating hyphal development and plasticity of dimorphism remain unclear. Here we show that hyphal development involves two sequential regulations of the promoter chromatin of hypha-specific genes. Initiation requires a rapid but temporary disappearance of the Nrg1 transcriptional represso

SUBMITTER: Lu Y 

PROVIDER: S-EPMC3139633 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature