Methylphenidate normalizes frontocingulate underactivation during error processing in attention-deficit/hyperactivity disorder.

ABSTRACT:

Background

Children with attention-deficit/hyperactivity disorder (ADHD) have deficits in performance monitoring often improved with the indirect catecholamine agonist methylphenidate (MPH). We used functional magnetic resonance imaging to investigate the effects of single-dose MPH on activation of error processing brain areas in medication-naive boys with ADHD during a stop task that elicits 50% error rates.

Methods

Twelve medication-naive boys with ADHD were scanned twice, under either a single clinical dose of MPH or placebo, in a randomized, double-blind design while they performed an individually adjusted tracking stop task, designed to elicit 50% failures. Brain activation was compared within patients under either drug condition. To test for potential normalization eff

SUBMITTER: Rubia K 

PROVIDER: S-EPMC3139835 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature