DCDC2, KIAA0319 and CMIP are associated with reading-related traits.

ABSTRACT:

Background

Several susceptibility genes have been proposed for dyslexia (reading disability; RD) and specific language impairment (SLI). RD and SLI show comorbidity, but it is unclear whether a common genetic component is shared.

Methods

We have investigated whether candidate genes for RD and SLI affect specific cognitive traits or have broad effect on cognition. We have analyzed common risk variants within RD (MRPL19/C2ORF3, KIAA0319, and DCDC2) and language impairment (CMIP and ATP2C2) candidate loci in the Avon Longitudinal Study of Parents and Children cohort (n = 3725), representing children born in southwest England in the early 1990s.

Results

We detected associations between reading skills and KIAA0319, DCDC2, and CMIP. We show that DCDC2 is specifically associ

SUBMITTER: Scerri TS 

PROVIDER: S-EPMC3139836 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature