Male circumcision and penile cancer: a systematic review and meta-analysis.

ABSTRACT:

Objective

We systematically reviewed the evidence of an association between male circumcision and penile cancer.

Methods

Databases were searched using keywords and text terms for the epidemiology of penile cancer. Random effects meta-analyses were used to calculate summary odds ratios (ORs) and 95% confidence intervals (CI).

Results

We identified eight papers which evaluated the association of circumcision with penile cancer, of which seven were case-control studies. There was a strong protective effect of childhood/adolescent circumcision on invasive penile cancer (OR = 0.33; 95% CI 0.13-0.83; 3 studies). In two studies, the protective effect of childhood/adolescent circumcision on invasive cancer no longer persisted when analyses were restricted to boys with no hist

SUBMITTER: Larke NL 

PROVIDER: S-EPMC3139859 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature