Discontinuation of low dose aspirin and risk of myocardial infarction: case-control study in UK primary care.

ABSTRACT:

Objectives

To evaluate the risk of myocardial infarction and death from coronary heart disease after discontinuation of low dose aspirin in primary care patients with a history of cardiovascular events.

Design

Nested case-control study.

Setting

The Health Improvement Network (THIN) database in the United Kingdom.

Participants

Individuals aged 50-84 with a first prescription for aspirin (75-300 mg/day) for secondary prevention of cardiovascular outcomes in 2000-7 (n=39,513).

Main outcome measures

Individuals were followed up for a mean of 3.2 years to identify cases of non-fatal myocardial infarction or death from coronary heart disease. A nested case-control analysis assessed the risk of these events in those who had stopped taking low dose aspirin compa

SUBMITTER: Rodriguez LA 

PROVIDER: S-EPMC3139911 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature