Effects of daily treatment with citicoline: a double-blind, placebo-controlled study in cocaine-dependent volunteers.

ABSTRACT:

Unlabelled

Many pharmacotherapies for treating cocaine dependence are aimed at reducing drug effects, alleviating craving, and preventing relapse. We demonstrated previously that citicoline, a compound used to repair neuronal damage in stroke and brain injury, is safe in cocaine-abusing volunteers.

Objectives

This study assessed the effectiveness of an 8-week citicoline treatment period and 4-week follow-up in cocaine-dependent individuals.

Methods

Twenty-nine healthy nontreatment-seeking, cocaine-dependent male and female volunteers were randomized in this double-blind, placebo-controlled study, 18 of whom completed the treatment period of the study. Participants took citicoline (500 mg twice daily) or matched placebo each day and recorded the measures of craving and

SUBMITTER: Licata SC 

PROVIDER: S-EPMC3140015 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature