Genetic polymorphisms in inflammation pathway genes and prostate cancer risk.

ABSTRACT:

Background

Chronic inflammation is an important mechanism for the development and progression of prostate cancer (PC). To better understand the potential relationship between genes in the inflammation pathway and PC risk, we evaluated variants in 16 candidate genes.

Methods

A total of 143 tagging and amino acid altering single nucleotide polymorphisms (SNPs) were genotyped in Caucasian and African American men participating in one of two population-based, case-control studies (n = 1,458 cases and 1,351 controls). The relative risk of PC was estimated using logistic and polytomous regression models.

Results

Ten SNPs in seven genes (CXCL12, IL4, IL6, IL6ST, PTGS2, STAT3, and TNF) were nominally associated (P < 0.05) with risk of PC in Caucasians. The most significant ef

SUBMITTER: Kwon EM 

PROVIDER: S-EPMC3140053 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature