Genetic associations with brain microbleeds: Systematic review and meta-analyses.

ABSTRACT:

Objective

We performed a systematic review and meta-analyses to assess the evidence for genetic associations with brain microbleeds (BMBs).

Methods

We sought all published studies of the association between any genetic polymorphism and BMBs studied in a total of >100 people. We critically appraised studies, and calculated pooled odds ratios (ORs) using the generic inverse variance fixed effects method. We used I² and χ² statistics to assess heterogeneity, and fail-safe N estimates to assess the robustness of our results.

Results

Only the APOE ε2/3/4 polymorphism had been studied in >100 people (10 studies, 7,351 participants). Compared with people with the ε3/ε3 genotype, carriers of the ε4 allele (ε4+) were statistically significantly more likely to have BMBs in any

SUBMITTER: Maxwell SS 

PROVIDER: S-EPMC3140069 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature