A lifespan analysis of intraneocortical connections and gene expression in the mouse II.

ABSTRACT: The mammalian neocortex contains an intricate processing network of multiple sensory and motor areas that allows the animal to engage in complex behaviors. These anatomically and functionally unique areas and their distinct connections arise during early development, through a process termed arealization. Both intrinsic, activity-independent and extrinsic, activity-dependent mechanisms drive arealization, much of which occurs during the areal patterning period (APP) from late embryogenesis to early postnatal life. How areal boundaries and their connections develop and change from infancy to adulthood is not known. Additionally, the adult patterns of sensory and motor ipsilateral intraneocortical connections (INCs) have not been thoroughly characterized in the mouse. In this report and its

SUBMITTER: Dye CA 

PROVIDER: S-EPMC3140181 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature