Transcriptomes of the B and T lineages compared by multiplatform microarray profiling.

ABSTRACT: T and B lymphocytes are developmentally and functionally related cells of the immune system, representing the two major branches of adaptive immunity. Although originating from a common precursor, they play very different roles: T cells contribute to and drive cell-mediated immunity, whereas B cells secrete Abs. Because of their functional importance and well-characterized differentiation pathways, T and B lymphocytes are ideal cell types with which to understand how functional differences are encoded at the transcriptional level. Although there has been a great deal of interest in defining regulatory factors that distinguish T and B cells, a truly genomewide view of the transcriptional differences between these two cells types has not yet been taken. To obtain a more global perspective of

SUBMITTER: Painter MW 

PROVIDER: S-EPMC3140206 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature