Exploiting publicly available biological and biochemical information for the discovery of novel short linear motifs.

ABSTRACT: The function of proteins is often mediated by short linear segments of their amino acid sequence, called Short Linear Motifs or SLiMs, the identification of which can provide important information about a protein function. However, the short length of the motifs and their variable degree of conservation makes their identification hard since it is difficult to correctly estimate the statistical significance of their occurrence. Consequently, only a small fraction of them have been discovered so far. We describe here an approach for the discovery of SLiMs based on their occurrence in evolutionarily unrelated proteins belonging to the same biological, signalling or metabolic pathway and give specific examples of its effectiveness in both rediscovering known motifs and in discovering novel one

SUBMITTER: Sayadi A 

PROVIDER: S-EPMC3140502 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature