Pathological outcomes associated with the 17q prostate cancer risk variants.

ABSTRACT:

Purpose

Recent studies have identified 2 distinct genetic variants along chromosome 17, including allele T of single nucleotide polymorphism rs4430796 on 17q12 and allele G of single nucleotide polymorphism rs1859962 on 17q24, that have been linked to prostate cancer risk. Less is known about tumor pathological features in carriers of these variants.

Materials and methods

Genotypes for regions 17q12 and 17q24 were determined in 759 white men with prostate cancer and compared to those in 790 healthy control volunteers using logistic regression. In patients with prostate cancer the Fisher exact or Kruskal-Wallis test was used as appropriate to assess the relationship(s) between clinical and pathological characteristics with 17q carrier status.

Results

The frequency of t

SUBMITTER: Helfand BT 

PROVIDER: S-EPMC3140699 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature