Phenotype in parkinsonian and nonparkinsonian LRRK2 G2019S mutation carriers.

ABSTRACT:

Objectives

Using a family study design, we describe the motor and nonmotor phenotype in probands with LRRK2 G2019S mutations and family members and compare these individuals to patients with idiopathic Parkinson disease (iPD) and unrelated controls.

Methods

Probands with G2019S mutations and their first-degree relatives, subjects with iPD, and unrelated control subjects were identified from 4 movement disorders centers. All underwent neurologic examinations and tests of olfaction, color vision, anxiety, and depression inventories.

Results

Tremor was more often a presenting feature among 25 individuals with LRRK2-associated PD than among 84 individuals with iPD. Subjects with LRRK2-PD had better olfactory identification compared with subjects with iPD, higher Beck Depr

SUBMITTER: Marras C 

PROVIDER: S-EPMC3140802 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature