Increased polymorphism near low-complexity sequences across the genomes of Plasmodium falciparum isolates.

ABSTRACT: Low-complexity regions (LCRs) within proteins sequences are often considered to evolve neutrally even though recent studies reported evidence for selection acting on some of them. Because of their widespread distribution among eukaryotes genomes and the potential deleterious effect of expansion/contraction of some of them in humans, low-complexity sequences are of major interest and numerous studies have attempted to describe their dynamic between genomes as well as the factors correlated to their variation and to assess their selective value. However, due to the scarcity of individual genomes within a species, most of the analyses so far have been performed at the species level with the implicit assumption that the variation both in composition and size within species is too small relativ

SUBMITTER: Haerty W 

PROVIDER: S-EPMC3140889 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature