Deltoid injections of risperidone long-acting injectable in patients with schizophrenia.

ABSTRACT:

Background

Risperidone long-acting injectable was previously approved for treatment of schizophrenia as biweekly injections in the gluteal muscle only. We present data on local injection-site tolerability and safety of risperidone long-acting injectable and comparability of systemic exposure of deltoid versus gluteal injections.

Methods

Risperidone long-acting injectable was administered in an open-label, single-dose, two-way crossover study, with patients randomized to receive either 25mg gluteal/37.5mg deltoid crossover in two treatment periods or 50mg gluteal/50mg deltoid injections crossover; each treatment period was separated by an 85-day observation period (Study 1) and an open-label, multiple-dose study (4 sequential 37.5mg or 50mg deltoid injections every 2 weeks) (

SUBMITTER: Quiroz JA 

PROVIDER: S-EPMC3140894 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature