Proteins with complex architecture as potential targets for drug design: a case study of Mycobacterium tuberculosis.

ABSTRACT: Lengthy co-evolution of Homo sapiens and Mycobacterium tuberculosis, the main causative agent of tuberculosis, resulted in a dramatically successful pathogen species that presents considerable challenge for modern medicine. The continuous and ever increasing appearance of multi-drug resistant mycobacteria necessitates the identification of novel drug targets and drugs with new mechanisms of action. However, further insights are needed to establish automated protocols for target selection based on the available complete genome sequences. In the present study, we perform complete proteome level comparisons between M. tuberculosis, mycobacteria, other prokaryotes and available eukaryotes based on protein domains, local sequence similarities and protein disorder. We show that the enrichment of

SUBMITTER: Meszaros B 

PROVIDER: S-EPMC3140968 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature