Aging causes collateral rarefaction and increased severity of ischemic injury in multiple tissues.

ABSTRACT:

Objective

Aging is a major risk factor for increased ischemic tissue injury. Whether collateral rarefaction and impaired remodeling contribute to this is unknown. We quantified the number and diameter of native collaterals and their remodeling in 3-, 16-, 24-, and 31-month-old mice.

Methods and results

Aging caused an "age-dose-dependent" greater drop in perfusion immediately after femoral artery ligation, followed by a diminished recovery of flow and increase in tissue injury. These effects were associated with a decline in collateral number, diameter, and remodeling. Angiogenesis was also impaired. Mechanistically, these changes were not accompanied by reduced recruitment of T cells or macrophages to remodeling collaterals. However, endothelial nitric oxide synthase signal

SUBMITTER: Faber JE 

PROVIDER: S-EPMC3141082 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature