Comparing fludeoxyglucose F18-PET assessment of regional cerebral glucose metabolism and [11C]dihydrotetrabenazine-PET in evaluation of early dementia and mild cognitive impairment.

ABSTRACT:

Objective

To compare assessment of regional cerebral metabolic changes with [(11)C]dihydrotetrabenazine (DTBZ)-positron emission tomography (PET) measurement of regional cerebral blood flow (K(1)) and fludeoxyglucose F18 (FDG)-PET measurement of regional cerebral glucose uptake (CMR(glc)) in a clinically representative sample of subjects with mild dementia and mild cognitive impairment (MCI).

Design

[(11)C]Dihydrotetrabenazine-PET K(1) and FDG-PET CMR(glc) measurements were performed.

Setting

University-based cognitive disorders clinic.

Participants

Fifty subjects with either mild dementia (Mini-Mental State Examination score > or = 18) or MCI. Their results were compared with those of 80 normal control subjects.

Main outcome measures

The DTBZ-PET region

SUBMITTER: Albin RL 

PROVIDER: S-EPMC3141210 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature