Molecular characterization and phylogenetic study of peste des petits ruminants viruses from north central states of Nigeria.

ABSTRACT:

Background

Peste des petits ruminants is an endemic disease of sheep and goats in Nigeria and vaccination has been the method of control but sporadic outbreaks have been reported. This study was carried out to characterize PPR viruses from outbreaks in 2007 and 2009 from Kaduna and Plateau States.

Results

Of the 33 clinical samples analysed, 51.52% (n = 17) were positive for F protein gene primers (F1/F2). All the samples had a sequence similarity of 98-100% among them and 92-97% with the reference vaccine (Nig 75/1) strain. The deduced amino acid homology ranges between 96.3-99.7%. Phylogenetically all the Nigerian sequences cluster with Nig 75/1 and Nig 76/1 in lineage 1.

Conclusions

PPR is still a problem in Kaduna and Plateau States of Nigeria. The strains involve

SUBMITTER: Luka PD 

PROVIDER: S-EPMC3141404 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature