An organogenesis network-based comparative transcriptome analysis for understanding early human development in vivo and in vitro.

ABSTRACT:

Background

Integrated networks hold great promise in a variety of contexts. In a recent study, we have combined expression and interaction data to identify a putative network underlying early human organogenesis that contains two modules, the stemness-relevant module (hStemModule) and the differentiation-relevant module (hDiffModule). However, owing to its hypothetical nature, it remains unclear whether this network allows for comparative transcriptome analysis to advance our understanding of early human development, both in vivo and in vitro.

Results

Based on this integrated network, we here report comparisons with the context-dependent transcriptome data from a variety of sources. By viewing the network and its two modules as gene sets and conducting gene set enrichment an

SUBMITTER: Fang H 

PROVIDER: S-EPMC3141417 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature