Mutator dynamics in sexual and asexual experimental populations of yeast.

ABSTRACT:

Background

In asexual populations, mutators may be expected to hitchhike with associated beneficial mutations. In sexual populations, recombination is predicted to erode such associations, inhibiting mutator hitchhiking. To investigate the effect of recombination on mutators experimentally, we compared the frequency dynamics of a mutator allele (msh2Δ) in sexual and asexual populations of Saccharomyces cerevisiae.

Results

Mutator strains increased in frequency at the expense of wild-type strains in all asexual diploid populations, with some approaching fixation in 150 generations of propagation. Over the same period of time, mutators declined toward loss in all corresponding sexual diploid populations as well as in haploid populations propagated asexually.

Conclusions

SUBMITTER: Raynes Y 

PROVIDER: S-EPMC3141426 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature