Immunoglobulin heavy chains in medaka (Oryzias latipes).

ABSTRACT:

Background

Bony fish present an immunological system, which evolved independently from those of animals that migrated to land 400 million years ago. The publication of whole genome sequences and the availability of several cDNA libraries for medaka (Oryzias latipes) permitted us to perform a thorough analysis of immunoglobulin heavy chains present in this teleost.

Results

We identified IgM and IgD coding ESTs, mainly in spleen, kidney and gills using published cDNA libraries but we did not find any sequence that coded for IgT or other heavy chain isotypes described in fish. The IgM - ESTs corresponded with the secreted and membrane forms and surprisingly, the latter form only presented two constant heavy chain domains. This is the first time that this short form of membrane

SUBMITTER: Magadan-Mompo S 

PROVIDER: S-EPMC3141427 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature