Characterization of single-nucleotide variation in Indian-origin rhesus macaques (Macaca mulatta).

ABSTRACT:

Background

Rhesus macaques are the most widely utilized nonhuman primate model in biomedical research. Previous efforts have validated fewer than 900 single nucleotide polymorphisms (SNPs) in this species, which limits opportunities for genetic studies related to health and disease. Extensive information about SNPs and other genetic variation in rhesus macaques would facilitate valuable genetic analyses, as well as provide markers for genome-wide linkage analysis and the genetic management of captive breeding colonies.

Results

We used the available rhesus macaque draft genome sequence, new sequence data from unrelated individuals and existing published sequence data to create a genome-wide SNP resource for Indian-origin rhesus monkeys. The original reference animal and two a

SUBMITTER: Fawcett GL 

PROVIDER: S-EPMC3141668 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature