GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.

ABSTRACT:

Background

Epidemiologic evidence suggests a heritable component to risk for sudden cardiac arrest independent of risk for myocardial infarction. Recent candidate gene association studies for community sudden cardiac arrests have focused on a limited number of biological pathways and yielded conflicting results. We sought to identify novel gene associations for sudden cardiac arrest in patients with coronary artery disease by performing a genome-wide association study.

Methods

Tagging SNPs (n = 338,328) spanning the genome were typed in a case-control study comparing 89 patients with coronary artery disease and sudden cardiac arrest due to ventricular tachycardia or ventricular fibrillation to 520 healthy controls.

Results

Fourteen SNPs including 7 SNPs among 7 genes

SUBMITTER: Aouizerat BE 

PROVIDER: S-EPMC3141757 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature