Identification of many microRNAs that copurify with polyribosomes in mammalian neurons.
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ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC314190 | biostudies-literature | 2004 Jan
REPOSITORIES: biostudies-literature
Publications
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons.
Kim John J Krichevsky Anna A Grad Yonatan Y Hayes Gabriel D GD Kosik Kenneth S KS Church George M GM Ruvkun Gary G
Proceedings of the National Academy of Sciences of the United States of America 20031222 1
Localized translation in mammalian dendrites may play a role in synaptic plasticity and contribute to the molecular basis for learning and memory. The regulatory mechanisms that control localized translation in neurons are not well understood. We propose a role for microRNAs (miRNAs), a class of noncoding RNAs, as mediators of neuronal translational regulation. We have identified 86 miRNAs expressed in mammalian neurons, of which 40 have not previously been reported. A subset of these miRNAs exh ...[more]
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