Does glucose variability influence the relationship between mean plasma glucose and HbA1c levels in type 1 and type 2 diabetic patients?

ABSTRACT:

Objective

The A1C-Derived Average Glucose (ADAG) study demonstrated a linear relationship between HbA(1c) and mean plasma glucose (MPG). As glucose variability (GV) may contribute to glycation, we examined the association of several glucose variability indices and the MPG-HbA(1c) relationship.

Research design and methods

Analyses included 268 patients with type 1 diabetes and 159 with type 2 diabetes. MPG during 3 months was calculated from 7-point self-monitored plasma glucose and continuous glucose monitoring. We calculated three different measures of GV and used a multiple-step regression model to determine the contribution of the respective GV measures to the MPG-HbA(1c) relationship.

Results

GV, as reflected by SD and continuous overlapping net glycemic action, h

SUBMITTER: Kuenen JC 

PROVIDER: S-EPMC3142023 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature