Weight-based, insulin dose-related hypoglycemia in hospitalized patients with diabetes.

ABSTRACT:

Objective

To determine the association of weight-based insulin dose with hypoglycemia in noncritically ill inpatients with diabetes.

Research design and methods

We performed a retrospective, case-control study of 1,990 diabetic patients admitted to hospital wards. Patients with glucose levels <70 mg/dL (case subjects) were matched one to one with nonhypoglycemic control subjects on the basis of the hospital day of hypoglycemia, age, sex, and BMI.

Results

Relative to 24-h insulin doses <0.2 units/kg, the unadjusted odds of hypoglycemia increased with increasing insulin dose. Adjusted for insulin type, sliding-scale insulin use, and albumin, creatinine, and hematocrit levels, the higher odds of hypoglycemia with increasing insulin doses remained (0.6-0.8 units/kg: odds

SUBMITTER: Rubin DJ 

PROVIDER: S-EPMC3142056 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature