Validation of the Diabetes Prevention Trial-Type 1 Risk Score in the TrialNet Natural History Study.

ABSTRACT:

Objective

We assessed the accuracy of the Diabetes Prevention Trial-Type 1 Risk Score (DPTRS), developed from the Diabetes Prevention Trial-Type 1 (DPT-1), in the TrialNet Natural History Study (TNNHS).

Research design and methods

Prediction accuracy of the DPTRS was assessed with receiver-operating characteristic curve areas. The type 1 diabetes cumulative incidence within the DPTRS intervals was compared between the TNNHS and DPT-1 cohorts.

Results

Receiver-operating characteristic curve areas for the DPTRS were substantial in the TNNHS (P < 0.001 at both 2 and 3 years). The type 1 diabetes cumulative incidence did not differ significantly between the TNNHS and DPT-1 cohorts within DPTRS intervals. In the TNNHS, 2-year and 3-year risks were low for DPTRS intervals <

SUBMITTER: Sosenko JM 

PROVIDER: S-EPMC3142063 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature