Novel locus FER is associated with serum HMW adiponectin levels.

ABSTRACT:

Objective

High molecular weight (HMW) adiponectin is a predominant isoform of circulating adiponectin and has been related to type 2 diabetes. Previous linkage studies suggest that different genetic components might be involved in determining HMW and total adiponectin levels.

Research design and methods

We performed a genome-wide association study (GWAS) of serum HMW adiponectin levels in individuals of European ancestry drawn from the Nurses' Health Study (NHS) (N = 1,591). The single nucleotide polymorphisms (SNPs) identified in the GWAS analysis were replicated in an independent cohort of Europeans (N = 626). We examined the associations of the identified variations with diabetes risk and metabolic syndrome.

Results

We identified a novel locus near the FER gene (5q

SUBMITTER: Qi L 

PROVIDER: S-EPMC3142072 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature