A genome-wide association study confirms previously reported loci for type 2 diabetes in Han Chinese.

ABSTRACT:

Background

Genome-wide association study (GWAS) has identified more than 30 loci associated with type 2 diabetes (T2D) in Caucasians. However, genomic understanding of T2D in Asians, especially Han Chinese, is still limited.

Methods and principal findings

A two-stage GWAS was performed in Han Chinese from Mainland China. The discovery stage included 793 T2D cases and 806 healthy controls genotyped using Illumina Human 660- and 610-Quad BeadChips; and the replication stage included two independent case-control populations (a total of 4445 T2D cases and 4458 controls) genotyped using TaqMan assay. We validated the associations of KCNQ1 (rs163182, p = 2.085×10(-17), OR 1.28) and C2CD4A/B (rs1370176, p = 3.677×10(-4), OR 1.124; rs1436953, p = 7.753×10(-6), OR 1.141; rs7172432, p

SUBMITTER: Cui B 

PROVIDER: S-EPMC3142153 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature