Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome.

ABSTRACT: Vertebrate embryos are derived from a transitory pool of pluripotent cells. By the process of embryonic induction, these precursor cells are assigned to specific fates and differentiation programs. Histone post-translational modifications are thought to play a key role in the establishment and maintenance of stable gene expression patterns underlying these processes. While on gene level histone modifications are known to change during differentiation, very little is known about the quantitative fluctuations in bulk histone modifications during development. To investigate this issue we analysed histones isolated from four different developmental stages of Xenopus laevis by mass spectrometry. In toto, we quantified 59 modification states on core histones H3 and H4 from blastula to tadpole st

SUBMITTER: Schneider TD 

PROVIDER: S-EPMC3142184 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature