Integrative network analysis reveals active microRNAs and their functions in gastric cancer.

ABSTRACT:

Background

MicroRNAs (miRNAs) are a class of endogenous, small and highly conserved noncoding RNAs that control gene expression either by degradation of target mRNAs or by inhibition of protein translation. They play important roles in cancer progression. A single miRNA can provoke a chain reaction and further affect protein interaction network (PIN). Therefore, we developed a novel integrative approach to identify the functional roles and the regulated PIN of oncomirs.

Results

We integrated the expression profiles of miRNA and mRNA with the human PIN to reveal miRNA-regulated PIN in specific biological conditions. The potential functions of miRNAs were determined by functional enrichment analysis and the activities of miRNA-regulated PINs were evaluated by the co-expression

SUBMITTER: Tseng CW 

PROVIDER: S-EPMC3142228 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature