Current source density measures of electroencephalographic alpha predict antidepressant treatment response.

ABSTRACT:

Background

Despite recent success in pharmacologic treatment of depression, the inability to predict individual treatment response remains a liability. This study replicates and extends findings relating pretreatment electroencephalographic (EEG) alpha to treatment outcomes for serotonergic medications.

Methods

Resting EEG (eyes-open and eyes-closed) was recorded from a 67-electrode montage in 41 unmedicated depressed patients and 41 healthy control subjects. Patients were tested before receiving antidepressants including a serotonergic mode of action (selective serotonin reuptake inhibitor [SSRI], serotonin and norepinephrine reuptake inhibitor, or SSRI plus norepinephrine and dopamine reuptake inhibitor). EEG was quantified by frequency principal components analysis of spe

SUBMITTER: Tenke CE 

PROVIDER: S-EPMC3142299 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature