Serotonin transporter gene polymorphism may be associated with functional dyspepsia in a Japanese population.

ABSTRACT:

Background

Although familial clustering of functional dyspepsia (FD) has been reported, the role of genetics in the susceptibility to FD is still not well understood. In the present study, the association between serotonin transporter (SERT) gene (SLC6A4) polymorphism and FD was explored.

Methods

Subjects were divided into either a postprandial distress syndrome (PDS) group or an epigastric pain syndrome (EPS) group according to the Rome III criteria. The healthy controls were those who had visited a hospital for an annual health check-up. The presence of the SLC6A4 promoter polymorphism, 5-hydroxytryptamin transporter gene linked polymorphic region (5-HTTLPR), was then evaluated, and logistic regression analysis was used to test all variables.

Results

The 5-HTTLPR ge

SUBMITTER: Toyoshima F 

PROVIDER: S-EPMC3142494 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature